• Mahesh Sunil Jadhawar
• Asst.Prof. Bhosale B.S
• Dr.Prachi .P. Udapurkar
• Dnyaneshwar Madhukar Andhale
• Kiran Shivaji Sonwane

The present research work done with an objective of preparation and evaluation of floating tablets of Tofacitinib Citrate drug with Hydroxy propylene methyl cellulose (HPMC), Polyox N- 60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.

Tofacitinib Citrate, Floating Tablets, Carbopol 934 P.

"Formulation and evaluation of tofacitinib citrate floating tablet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.a205-a222, July-2024, Available :http://www.jetir.org/papers/JETIR2407021.pdf

"Formulation and evaluation of tofacitinib citrate floating tablet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppa205-a222, July-2024, Available at : http://www.jetir.org/papers/JETIR2407021.pdf