• INDURU JAGADEESH
• L. SINDHUJA REDDY
• S. VARSHA
• K. SRINIJA

Hair styling and hair grooming is an age old phenomena, forms an integral part of the consumer’s need for both men and women. Hair creams improve the dull and dry hairs. Hair creams of oil in water emulsions type are particularly beneficial because when the external aqueous phase is absorbed/evaporated, the emulsion breaks and the remaining oil forms a protective film on the hair shaft provides both protection and nourishment. The vitamin E loaded hair creams were formulated using Plackett Burman screening design, by preparing dummy bases first and finally incorporating vitamin E later. The prepared creams were evaluated for different critical quality attributes. All formulations were found to be white and semisolid in nature. The glossy nature was found to be shiny to very shiny and none of the formulations was dull. Washability was found to be satisfactory and none of the formulations fall in non-washable criteria. The spreadability of all the formulations was in the range of 4.0 to 5.5 cm. Among all, F7 formulation was found to be the best based on high CQA score of 10.7. The pH of the creams was in acceptable range from 5 to 9 and hence all the formulations may be non-irritant to scalp. The viscosity data showed the decrease in the viscosity with increase in RPM, hence hair cream F7 is shear thinning Non-Newtonian system. The in vitro free radical scavenging activity of 400 mg hair cream F7 was found to 2.44%. The vitamin E content of the best formulation (F7) was found to be 1.98 gm/100 gm of cream which is 99% of theoretical label claim. In conclusion, the vitamin E loaded hair creams is a better alternative to daily vitamin E dietary supplements.

Hair creams, Vitamin E, CQA scores , Viscosity, pH, drug content, free radical scavenging activity

"Design and evaluation of vitamin E hair creams, Plackett Burman Screening design with seven variables at two levels", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.a282-a288, July-2024, Available :http://www.jetir.org/papers/JETIR2407025.pdf

"Design and evaluation of vitamin E hair creams, Plackett Burman Screening design with seven variables at two levels", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppa282-a288, July-2024, Available at : http://www.jetir.org/papers/JETIR2407025.pdf