• Sameer Dixit
• Arun K Sikarwar

Quantitative structure-activity relationship (QSAR) is a statistical modelling approach mostly used in molecular modelling, property and activity prediction of new molecule, drug discovery and prediction of environment. For a best QSAR model Validation of model is an important step. Validation is a step to check the reliability and robustness of QSAR models. The use of statistical approaches in drug discovery is of more crucial due to several reasons. These approaches help in the efficient and effective identification and development of new drugs by providing robust, reliable, and quantitative methods to analyze complex biological data. In this paper some key points highlighting the significance of statistical approaches in drug discovery.

QSAR, Molecular descriptors, correlation coefficient. PRESS, SPRESS, R2cv, PSE, LSE

"Validation of QSAR Models Using External Statistical Approach in Drug Discovery", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.a672-a676, July-2024, Available :http://www.jetir.org/papers/JETIR2407063.pdf

"Validation of QSAR Models Using External Statistical Approach in Drug Discovery", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppa672-a676, July-2024, Available at : http://www.jetir.org/papers/JETIR2407063.pdf