• Ritu
• Shaily Mishra
• Dr. Shamim Ahmad

Diabetes mellitus is a global health concern, necessitating the exploration of new therapeutic agents for effective management. Soybean (Glycine max), recognized for its rich nutritional profile, has shown promise in diabetes treatment due to its bioactive constituents. This study aims to evaluate the anti-diabetic activity of soybean seeds through a systematic investigation of their biochemical properties, mechanisms of action, and efficacy in clinical settings. Soybean seeds are abundant in isoflavones, proteins, saponins, and dietary fibers, each contributing uniquely to anti-diabetic effects. Isoflavones, especially genistein and daidzein, have demonstrated significant roles in enhancing insulin sensitivity, modulating glucose metabolism, and exerting insulin-like actions. Soy proteins and their hydrolysates further contribute to improving insulin secretion and reducing insulin resistance by enhancing the expression of insulin receptor substrate (IRS) and glucose transporter type 4 (GLUT4). Experimental studies, including in vitro assays and animal models, have shown that soybean seed extracts can significantly lower blood glucose levels and improve insulin sensitivity. Clinical trials have further corroborated these findings, indicating that regular soybean consumption can lead to reductions in fasting blood glucose, glycated hemoglobin (HbA1c), and improvements in lipid profiles among diabetic patients.

Soybean seeds, anti-diabetic activity, isoflavones, genistein, insulin resistance, glucose metabolism, clinical evaluation, dietary fiber

"Research paper on Evaluation of Soybean Seed for Antidiabetic Activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.b851-b864, July-2024, Available :http://www.jetir.org/papers/JETIR2407192.pdf

"Research paper on Evaluation of Soybean Seed for Antidiabetic Activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppb851-b864, July-2024, Available at : http://www.jetir.org/papers/JETIR2407192.pdf