• Rohit Dongre
• Dr. Suchi Jain
• Dr. Sachin Kumar

For the simultaneous measurement of valsartan and hydrochlorothiazide in a tablet dosage form, two UV-spectrophotometric techniques have been devised and validated. Using the absorbance measurements for valsartan and hydrochlorothiazide at two wavelengths (249.4 nm and 272.6 nm, respectively), the first technique included solving simultaneous equations. The Q-absorbance equation is formed at the isoabsorptive point of 258.4 nm and the hydrochlorothiazide peak of 272.6 nm in the absorbance ratio method, which was the second technique used. The results showed that, using 0.1 N NaOH as the solvent, the procedures were linear in the range of 5–30 μg/mL for valsartan and 4–24 μg/mL for hydrochlorothiazide. For valsartan and hydrochlorothiazide, respectively, at three different levels of standard adds, the mean percentage recovery was determined to be 100.20% and 100.19% for the simultaneous equation approach and 98.56% and 97.96% for the absorbance ratio method. The approaches' accuracy (intraday and interday) was confirmed to be within bounds. The present investigation's results suggest that two methods for simultaneously estimating valsartan and hydrochlorothiazide in tablet dosage form are straightforward, quick, accurate, precise, and cost-effective. These methods can be successfully applied to routine laboratory analyses and quality control pharmaceutical formulations.

Valsartan, Hydrochlorothiazide, Absorbance ratio, Standard solution, Simultaneous

"Development and Validation of Analytical Methods for Estimation of Valsartan and HCTZ ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.d302-d311, July-2024, Available :http://www.jetir.org/papers/JETIR2407330.pdf

"Development and Validation of Analytical Methods for Estimation of Valsartan and HCTZ ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppd302-d311, July-2024, Available at : http://www.jetir.org/papers/JETIR2407330.pdf