• Muthu Krishnan
• Rajaguru Gangatharan

Medicinal plants include endophytic fungus that can create a range of bioactive chemicals with different pharmaco-potentials. The endophytic fungi Fusarium solani and Curuvularia hominis were isolated from different medicinal plants. GC-MS examination of endophytic fungus' intra- and extracellular products showed the presence of a variety of bioactive compounds, including n-Hexadecanoic acid, Tridecanoic acid, cis-Vaccenic acid, 6-Octadecenoic acid, Chloromethyl 11-chlorododecanoate, Benzene, tert-Butyl(5-isopropyl-2-methylphenoxy) dimethylsilane, 9,12-Octadecadienoic acid, Z,Z-4,15-Octadecadien-1-ol Acetate, 9-Octadecenoic acid, cis-13-Octadecenoic acid, cis-Vaccenic acid, Octadecanoic acid, Glycerol 1-palmitate, Triazin, Eicosane, Oleic Acid, Acetamide, 2,2,2-trifluoro-N, pennogenin diacetate, 1,2,3-propanetr,doecanoic acid 1,2,3-propanetr,acetamide,2,2,2-trifluoro-N-,colchiceine,N-desacetyl-n-T-FA,Acetamide,2,2,2-trifluoro-n-(5),5-(4-chlorophenyl)-6-ethyl,5alpha-cyano-3-methoxymethylen, anti-microbial, anti-fungal, anti-HIV, antitumor, anthelmintic, solubilizing agent, anti-cancer, antiviral, fungicidal, insecticidal, bactericidal, herbicidal, antimalarial and antimicrobial agents. The phytochemical composition analysis of endophytic extracts also revealed the presence of flavonoids, phenols, saponins, carbohydrates, glycosides, alkaloids and proteins. The intra and extracellular endophytic extracts exhibited strong antibacterial and antioxidant activity, which was screened with the agar well diffusion method and DPPH, H2O2 activity respectively. Therefore, the isolated endophytic fungal species can be utilized to generate a variety of bioactive chemicals from natural sources that utilized in the creation of innovative therapeutics and lessen the environmental impact of manufactured chemical drugs.

Bioactive compounds, Entophytic fungi, antibacterial, GC-MS, FTIR, Phytochemical study, Anticancer, antiviral activity.

"NATURAL BIOACTIVE COMPOUNDS SYNTHESIS IN ENDOPHYTIC MICRO-FUNGI FROM VARIETY OF THERAPEUTIC PLANTS IN SIVAKASI, TAMIL NADU", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.e169-e200, July-2024, Available :http://www.jetir.org/papers/JETIR2407421.pdf

"NATURAL BIOACTIVE COMPOUNDS SYNTHESIS IN ENDOPHYTIC MICRO-FUNGI FROM VARIETY OF THERAPEUTIC PLANTS IN SIVAKASI, TAMIL NADU", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppe169-e200, July-2024, Available at : http://www.jetir.org/papers/JETIR2407421.pdf