• Miss. Pooja B. Sankpal
• Mr. Omkar Marathe
• Mr. Prasad P. Yadav
• Dr. Nilesh Chougule

Toxicology is "the science of poisons"; notably, the study of the chemical and physical features of poisons and their physiological or behavioral consequences on organisms; and both quantitative and qualitative approaches for their examination., and the creation of poisoning treatment protocols. The twentieth century saw a significant advancement in toxicological knowledge. The evaluation of the safety and toxicity profile of new chemical or biological entities is an essential component of pharmaceutical development. Despite continued attempts to better understand the mechanisms underpinning safety and toxicity, safety concerns continue to account for approximately 30% of drug discovery and development attrition rates. In this review, we will focus on the implications of current practice for drug development and consider the scientific and ethical requirements for the evaluation of safety and toxicity. Toxicological screening is critical for the development of new medications and expanding the therapeutic potential of current compounds. According to the US Food and Drug Administration (FDA), screening novel compounds for pharmacological action and toxicity in animals is critical (21CFR Part 314). In the twenty-first century, the harmful effects of chemicals, dietary items, medications, and so on have become increasingly important. This brief research emphasizes on the historical significance of toxicological screening as well as alternative and particular methodologies that employ a variety of experimental animal models.

Toxicity, Acute toxicity, Toxicology, Ethics, Screening, Mutagenic, Genetic toxicity

"TOXICITY : a review on toxicological assessments", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.g327-g334, July-2024, Available :http://www.jetir.org/papers/JETIR2407638.pdf

"TOXICITY : a review on toxicological assessments", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppg327-g334, July-2024, Available at : http://www.jetir.org/papers/JETIR2407638.pdf