• Vanaja Kune
• Kishore Salikineedy

This study investigates the impact of Nardostachys jatamansi extract (NJEt) and nicotine (Nt) on creatine phosphokinase (CPK) activity in the skeletal muscle of young (3 months) and old (18 months) male albino rats. Over a period of two months, CPK activity was measured in both age groups. In young rats, skeletal muscle CPK activity was 35.02 μmoles/mg protein/hour in the control group, decreased to 31.74 μmoles/mg protein/hour with nicotine treatment, increased to 41.10 μmoles/mg protein/hour with NJEt treatment, and was 34.16 μmoles/mg protein/hour with the combined NJEt and nicotine treatment. In old rats, skeletal muscle CPK activity was 30.35 μmoles/mg protein/hour in the control group, decreased to 26.74 μmoles/mg protein/hour with nicotine treatment, increased to 36.04 μmoles/mg protein/hour with NJEt treatment, and was 29.61 μmoles/mg protein/hour with the combined NJEt and nicotine treatment. These results indicate significant alterations in CPK activity in response to NJEt and nicotine treatments, both individually and in combination. Nicotine treatment significantly decreased CPK activity in both young and old rats, while NJEt treatment led to a significant increase. The combined treatment of NJEt and nicotine mitigated the nicotine-induced reductions in CPK activity. Three-way ANOVA revealed significant interactions between tissue type, age, and treatment, indicating the complex interplay between these factors. The findings suggest that NJEt has a protective effect against nicotine-induced alterations in skeletal muscle, potentially due to its antioxidant properties.

"Impact of Nardostachys jatamansi Extract and Nicotine on Creatine Phosphokinase Activity in Skeletal Muscle of Young and Old Male Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.g715-g719, July-2024, Available :http://www.jetir.org/papers/JETIR2407680.pdf

"Impact of Nardostachys jatamansi Extract and Nicotine on Creatine Phosphokinase Activity in Skeletal Muscle of Young and Old Male Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppg715-g719, July-2024, Available at : http://www.jetir.org/papers/JETIR2407680.pdf