• D. Sripriya

Diabetes mellitus is a chronic disease characterised by insulin insufficiency, which results in hyperglycaemia and causes acute and chronic consequences. The goal of this study is to determine the antidiabetic activity of methanol extracts of five medicinal plants in vitro using an enzyme inhibition test for α-amylase and α-glucosidase. The study used acarbose and methanol extracts from all five plants at doses of 10, 20, 30, 40, 50, 60, 70, and 80 µg/ml. The absorbance values for -amylase and α-glucosidase enzymes were measured in a spectrophotometer at 540 nm and 546 nm, respectively. The extracts significantly inhibited the enzymes -amylase and α-glucosidase in a dose-dependent manner. When compared to other plants, Phyllanthus madraspetensis methanol extract had greater inhibitory effect against α-amylase and α-glucosidase enzymes. We concluded that Phyllanthus madraspetensis methanol extract showed better antidiabetic effect in in vitro models based on our findings. This finding calls for more research and animal model tests.

Diabetes mellitus, alpha-glucosidase, alpha-amylase

"In vitro evaluation of antidiabetic activity of methanol extracts of selected medicinal plants", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.h429-h437, July-2024, Available :http://www.jetir.org/papers/JETIR2407756.pdf

"In vitro evaluation of antidiabetic activity of methanol extracts of selected medicinal plants", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. pph429-h437, July-2024, Available at : http://www.jetir.org/papers/JETIR2407756.pdf