• Vishal CS
• Dr Ashwini Rajendra

Olmesartan medoxomil is BCS class II drug which is poorly water soluble and highly permeable in nature. Lower solubility leads to poor dissolution and inadequate bioavailability. The aim of this work was to improve the solubility of poorly aqueous soluble drug Olmesartan medoximil using Poloxamer 407 and HPMC K 15 M by solid dispersion technique. Ternary solid dispersion were prepared by solvent evaporation methods. Phase solubility study of all the formulations was carried out in distilled water .). Fast dissolving tablets of Olmesartan medoximil were formulated using selected solid dispersion and superdisintegarnt. Stability studies were carried out for selected formulation. In the phase solubility study the solubility of drug carrier mixture was found in the range between 10.428 to 21.610 mg/ml. The plot of concentration of drug verses concentration of carrier showed linearity with the regression coefficient value less than 1, indicating AN type of curve. The compatibility studies indicated the conversion of crystalline form of Olmesartan medoximil to amorphous form. Fast dissolving tablets of selected formulation showed 90.8% release in 1 hour. The formulations were stable during the study period. From the results it can be concluded that solvent evaporation technique can be utilized to prepare solid dispersion which are successfully formulated into fast dissolving tablets.

Solvent evaporation method, Olmesartan Medoximil, Fast dissolving tablets.

"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF OLMESARTAN MEDOXOMIL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.h522-h532, July-2024, Available :http://www.jetir.org/papers/JETIR2407763.pdf

"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF OLMESARTAN MEDOXOMIL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. pph522-h532, July-2024, Available at : http://www.jetir.org/papers/JETIR2407763.pdf