• Vd. Mugdha Gore
• Dr. M. S. Cholera
• Prof. Vd. Arpan Bhatt

Abstract Introduction: The evolving lifestyle has given rise to various lifestyle disorders, Amlapitta is one of the gastrointestinal disorders presenting symptoms such as retrosternal burning, nausea, and vomiting among others. Current medications for hyperacidity include Antacids, H2 Blockers, Proton Pump Inhibitors among others. However, they have side effects such as H2 Blockers (diarrhea, constipation, fatigue, drowsiness, headache, and muscle aches). PPI (headache, rash, dizziness, and gastrointestinal symptoms including nausea, abdominal pain, flatulence, constipation, and diarrhea.) Avipattikara Churna mentioned first in Bhaishajya Ratnavali is an effective drug in Ayurveda in treating Amlapitta. However, nearly half of its composition is Sharkara (sugar), which, being hygroscopic, absorbs moisture when exposed to humidity, potentially leading to fungal contamination. This compromises the shelf life of the formulation. Thus it is important to evaluate the baseline microbial stability of Avipattikara Churna. Aim: To evaluate the stability of Avipattikara Churna and monitor microbial contamination in the finished product over varying time intervals and under diverse climatic conditions, temperature, and humidity settings Materials and methods: Samples of Avipattikara Churna (stored at room temperature) were studied to inspect microbial contamination under different climatic conditions for 240 days The initial microbiological study was done on the 35th day of preparation, just before its oral administration to the patients. Then samples from same container were subjected to the microbiological study regularly with random intervals during different seasons for a period of 8 months. Result: In the present study, the stability study of Avipattikara Churna concerning microbiological findings was negative at room temperature, warm and cold, and dry and humid conditions for 240 days. Keywords: Avipattikara Churna, Microbial profile, Stability study

Avipattikara Churna, Microbial profile, Stability study

"Evaluation of Baseline Microbial Stability of Avipattikara Churna used in the treatment of Amlapitta", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 7, page no.i188-i199, July-2024, Available :http://www.jetir.org/papers/JETIR2407823.pdf

"Evaluation of Baseline Microbial Stability of Avipattikara Churna used in the treatment of Amlapitta", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 7, page no. ppi188-i199, July-2024, Available at : http://www.jetir.org/papers/JETIR2407823.pdf