• Ritu Ravi
• Kapil Yadav
• Praveen Tripathi
• Monika Singh
• Dr. Rajendra Kumar

Investigation of metal complexes with biologically active ligands has significant scientific and practical value. In this study, we focused on examining the formation of binary and ternary complexes involving metal ions such as Cu (II), Ni (II), Co (II) and Zn (II) with two biologically important ligands: glutamine (A) as the primary ligand and adenine (B) as the secondary ligand. To assess the complexation behaviour of these species in aqueous media, a potentiometric technique was employed at a temperature of 37±1°C and an ionic strength of I = 0.1 M NaNO3. The stability constants of the complexes were determined using the method proposed by Irving and Rossetti, and then refined using the SCOGS computer program. The results revealed that the formation of mixed-ligand ternary complexes occurred simultaneously in most cases, typically at higher pH values, leading to a gradual decrease in the concentration of the binary complexes for the respective metal ions. The binary and ternary species examined are shown in the species distribution curve. The protonation constant of the ligands and the stability constant of their complexes with metal ions are shown in the order of MA, MB, and MAB.

Chelation, Biomolecules, Potentiometric studies, Transition metal ions, Formation constant, SCOGS.

"pH-metric studies on formation constant of ternary metal complexes of glutamine and adenine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 8, page no.e44-e51, August-2024, Available :http://www.jetir.org/papers/JETIR2408405.pdf

"pH-metric studies on formation constant of ternary metal complexes of glutamine and adenine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 8, page no. ppe44-e51, August-2024, Available at : http://www.jetir.org/papers/JETIR2408405.pdf