UGC Approved Journal no 63975(19)
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ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 11 Issue 8
August-2024
eISSN: 2349-5162

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JETIR2408425


Registration ID:
546886

Page Number

e261-e271

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Title

IN VIVO & INVITRO EVALUATION OF ANTIDEPRESSANT ACTIVITY OF SPIRULINA & CLOPIDEGEROL IN EXPERIMENTAL ANIMALS

Abstract

To date, the search for novel pharmacotherapy from various medicinal plants and their constituents for psychiatric illnesses has significantly progressed. The present study was undertaken to evaluate the antidepressant potential of spirulina & clopidegerol in different animal models like forced swim test (FST).In this study spirulina & clopidegerol, at two dose (150,300 mg/kg & 75,150 mg/kg) respectively, and standard imipramine stock solution prepared with Sodium-CMC (15 mg/kg) were administered on test day to separate groups of Wistar rats and albino mice. From these two animal models it was found that, spirulina & clopidegerol showed significant reduction in the duration of immobility in FST at both dose levels in dose dependent manner and the effect of high dose i.e.300 of spirulina & 150 mg/kg of clopidegerol was compared with imipramine. spirulina & clopidegerol also showed significant antidepressant effect compared to imipramine preparation, study confirmed that spirulina & clopidegerol increase the neurotransmitter levels of NA, DA, 5HT suggesting neurotransmission modulation is a probable mechanism of action. spirulina & clopidegerol possesses significant antidepressant activity.

Key Words

Antidepressant activity, spirulina & clopidegerol, imipramine Forced swim test, Tail suspension test, Serotonin, Noradrenalin, Dopamine.

Cite This Article

"IN VIVO & INVITRO EVALUATION OF ANTIDEPRESSANT ACTIVITY OF SPIRULINA & CLOPIDEGEROL IN EXPERIMENTAL ANIMALS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 8, page no.e261-e271, August-2024, Available :http://www.jetir.org/papers/JETIR2408425.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"IN VIVO & INVITRO EVALUATION OF ANTIDEPRESSANT ACTIVITY OF SPIRULINA & CLOPIDEGEROL IN EXPERIMENTAL ANIMALS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 8, page no. ppe261-e271, August-2024, Available at : http://www.jetir.org/papers/JETIR2408425.pdf

Publication Details

Published Paper ID: JETIR2408425
Registration ID: 546886
Published In: Volume 11 | Issue 8 | Year August-2024
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.41119
Page No: e261-e271
Country: pune, maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication
Published Paper URL :: https://www.jetir.org/view?paper=JETIR2408425
Published Paper PDF: https://www.jetir.org/papers/JETIR2408425

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