• Shamanthakamani S L
• Yogananda R
• Maruthi N
• Nagaraja T S
• Snehalatha

Recent studies has been found that discovering and developing of new medication attaining a inefficiency in their therapeutic action, the main reason for low therapeutic action is that poor solubility, permeability and low oral bioavailability of API (that limits growth of a new product). To overcome these problem co-crystallization methods is adopted to enhance solubility, dissolution rate and bioavailability of API. Co-crystallization is a novel approach to improve physicochemical properties of API, Co-crystals which formed with API and Co-former does not alter the physicochemical as well as pharmacological activity of API, though this approach will enhance solubility, dissolution rate, bioavailability as well as stability of API. In this review we focused on properties of Co-crystal, selection of Co-former which plays a major role in formation of Co-crystals, various methods of preparation of Co-crystal like Solid based and Liquid based technique, Characterization of prepared Co-crystals include Melting point, FTIR, DSC etc, Co-crystal which are available as Marketed product and patent works on Co-crystals were reviewed to understand in depth about Co-crystallization technique.

Co-crystallization, Solubility, Dissolution rate, Bioavailability, Co-former

"An overview: Solubility Enhancement of Poorly Soluble Drugs by Co-crystallization technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 9, page no.e756-e766, September-2024, Available :http://www.jetir.org/papers/JETIR2409497.pdf

"An overview: Solubility Enhancement of Poorly Soluble Drugs by Co-crystallization technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 9, page no. ppe756-e766, September-2024, Available at : http://www.jetir.org/papers/JETIR2409497.pdf