• DR. SIDDHI UPADHYAY
• HIMANSHU MISHRA
• DRASHTI PANCHOLI
• ANAMIKA RAJPUT
• DR. UMESH UPADHYAY

Liquid Chromatography-Mass Spectrometry (LC-MS) has emerged as a powerful analytical technique for the separation, identification, and quantification of a wide range of compounds in complex samples. This hyphenated approach, combining liquid chromatography with mass spectrometry, has revolutionized the field of analytical chemistry by offering enhanced sensitivity, selectivity, and versatility. LC-MS has found applications in diverse scientific disciplines, including pharmaceuticals, environmental analysis, metabolomics, and proteomics. overview of the fundamental principles, components, and applications of the LC- MS technique. It explores the role of liquid chromatography in separating analytes based on their chemical properties and the subsequent mass spectrometric analysis for characterizing compounds through their mass-to-charge ratios and fragmentation patterns. Various LC-MS configurations, such as triple quadrupole, time-of-flight, and Orbitrap mass analyzers, are discussed, each offering unique capabilities for specific analytical challenges. It highlights the ability of LC-MS to identify and quantify trace levels of compounds in complex matrices, making it an invaluable tool for addressing analytical questions in both research and routine analysis.

Hyphenated Technique ,Chromatographic Analysis, Liquid Chromatography- Mass Spectrometry technique, LC-MS Applications, Method Optimisation of LC-MS, Spectrometry, LC-MS Instrumentation

"A REVIEW ON HYPHENATED TECHNIQUE LIQUID CHROMATOGRAPHY- MASS SPECTROSCOPY (LC-MS)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 9, page no.g42-g61, September-2024, Available :http://www.jetir.org/papers/JETIR2409604.pdf

"A REVIEW ON HYPHENATED TECHNIQUE LIQUID CHROMATOGRAPHY- MASS SPECTROSCOPY (LC-MS)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 9, page no. ppg42-g61, September-2024, Available at : http://www.jetir.org/papers/JETIR2409604.pdf