• AGHAV SONALI DATTATRAY
• Aher trupti chandrakanth
• Alam ayesha ahemad
• Ahire gayatri bhimaji
• Dr Gokul Talele

ABSTRACT Herb-drug interactions represent a significant concern in modern healthcare due to the increasing use of herbal supplements alongside conventional medications. Herbal products can influence the pharmacokinetics and pharmacodynamics of drugs, potentially leading to altered therapeutic outcomes or adverse effects. Key mechanisms of interaction include modulation of drug-metabolizing enzymes (such as cytochrome P450) and transport proteins (like P-glycoprotein), which can result in either increased toxicity or reduced efficacy of the co-administered drugs. Commonly used herbs such as St. John’s Wort, Ginkgo biloba, Ginseng, and Garlic have been reported to interact with a wide range of drugs, including anticoagulants, immunosuppressants, and antidepressants. Clinical outcomes of these interactions can range from mild to severe, emphasizing the need for healthcare professionals to recognize and manage potential herb-drug interactions effectively. Despite the growing body of evidence, challenges in studying herb-drug interactions include variability in herbal product composition, lack of standardization, and limited clinical data. This review aims to provide an overview of the mechanisms, common examples, and clinical implications of herb-drug interactions. Increased awareness and understanding among healthcare providers and patients are crucial for minimizing risks and ensuring the safe use of herbal and conventional medicines concurrently.

Interaction,ginseng,garlic herb,cytochrome p450

"Herb Drug Interaction:An reveiw", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 10, page no.a213-a222, October-2024, Available :http://www.jetir.org/papers/JETIR2410027.pdf

"Herb Drug Interaction:An reveiw", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 10, page no. ppa213-a222, October-2024, Available at : http://www.jetir.org/papers/JETIR2410027.pdf