• Sourabh Mishra
• Dr. Amit Dubey
• Dr. Jagdish Chandra Rathi

Nicotine present in tobacco is addictive & makes the process of quitting very prolonged & complex. Nicotine causes pulmonary diseases, lung cancer & heart diseases. Quitting smoking drastically reduces risk of dying from tobacco-related diseases. The current established procedures for smoking cessation have wide variety of side effects. Orodispersible Tablets based on Nicotine Polacrilex were created via direct compression. Preformulation study was performed. Melting point was found to be 80-82˚C by capillary tube method. There was no discernible interaction, indicating compatibility, between the medication and excipients. Pre compression parameters and Post-compression parameters were used to optimize and evaluate the prepared batches and found suitable. Wetting time and water absorption ratio for the best formulation (F3) were determined to be 26.23 seconds and 91.06%, respectively. In-vitro drug release for the optimized formulation (F3) was 99.80% within 25 minutes. Based on the aforementioned findings it was concluded that the combination of Cosspovidone and Methyl Cellulose PH 10 was shown to be the best superdisintegration for the preparation of Nicotine Polacrilex Orodispersible.

Orodispersible, superdisintegration, Preformulation, Cosspovidone and Methyl Cellulose

"Formulation and Evaluation of Nicotine Polacrilex Orodispersible Tablet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 10, page no.c713-c717, October-2024, Available :http://www.jetir.org/papers/JETIR2410375.pdf

"Formulation and Evaluation of Nicotine Polacrilex Orodispersible Tablet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 10, page no. ppc713-c717, October-2024, Available at : http://www.jetir.org/papers/JETIR2410375.pdf