UGC Approved Journal no 63975(19)

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Published in:

Volume 11 Issue 10
October-2024
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2410411


Registration ID:
549581

Page Number

e94-e116

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Title

DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF TRIAMCINOLONE ACETONIDE FOR CHRONIC SINUSITIS

Abstract

Aim : The aim of the present work was to develop therapeutically effective controlled release mucoadhesive microspheres of triamcinolone acetonide. Materials and Method: Triamcinolone acetonide microspheres with a coat consisting of alginate and a mucoadhesive polymerchitosan and Hydroxypropyl methyl cellulose (HPMC),were prepared by an ionotropic gelation technique. The microspheres were evaluated for FTIR studies, particle size ,drug entrapment efficiency, percentage yield, swelling index, in-vitro mucoadhesive test and in-vitro release studies. Results:The resulting microspheres were spherical and free flowing . The drug entrampment efficiency was 88.33±2.33. The microspheres exhibited good mucoadhesive property in the in-vitro mucoadhesive test. Conclusions : Among the other six formulations, Formula F6 emerged as an emerging formulation that provided us with viable and acceptable readings.This study is a little addition to the field of nasal medicine delivery, and it also attempts to lessen the frequency with which patients with chronic sinusitis encounter administration issues.

Key Words

Microsphere, Mucoadhesive, chronic sinus, Triamcinolone Acetonide

Cite This Article

"DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF TRIAMCINOLONE ACETONIDE FOR CHRONIC SINUSITIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 10, page no.e94-e116, October-2024, Available :http://www.jetir.org/papers/JETIR2410411.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF TRIAMCINOLONE ACETONIDE FOR CHRONIC SINUSITIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 10, page no. ppe94-e116, October-2024, Available at : http://www.jetir.org/papers/JETIR2410411.pdf

Publication Details

Published Paper ID: JETIR2410411
Registration ID: 549581
Published In: Volume 11 | Issue 10 | Year October-2024
DOI (Digital Object Identifier):
Page No: e94-e116
Country: Sonipat, Sonipat, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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