• Ms. Rajmane Ragini Baburao
• Ms. Desai Dhanshri J
• Ms. Sonali Bhagat B.
• Dr. Joshi Amol A

Oral is the most convenient route of drug administration, as it provides numerous advantages over others. In drug discovery, currently the number of drugs with water insolubility has increased, with almost 70% of newly developed drugs showing poor water solubility. Low drug solubility causes sluggish drug absorption, insufficient and inconsistent bioavailability, and toxicity of the gastrointestinal mucosa at the site of absorption. Thus, formulation scientist has a major challenge to make poorly water-soluble drugs more soluble. Several methods have been employed to increase the solubility, dissolution, and further bioavailability of water-insoluble drugsImproving drug dissolving and solubility without affecting their chemical structure is a significant problem. Since most therapeutic medications have structural specificity and about 85% of marketed drugs are crystal products, the crystal structure of the drug is a critical component in determining its efficacy. Therefore, a crystal engineering strategy has been an alternate and possibly effective way of dealing with the problem of low water solubility. Therefore, pharmaceutical cocrystals are one of the most rapidly developing categories of solid medicinal compounds. This review article gives a general review of pharmaceutical cocrystals, advances in their preparation techniques, aspects of cocrystal-based drug formulation, and difficulties encountered during its development.

Cocrystals, Coformers, Poorly water soluble drugs, Solution based methods, cocrystal based drug formulation

"A Brief Review On Pharmaceutical Cocrystals: Advances In Methods Of Preparation And Formulation-Based Aspect ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 10, page no.e857-e865, October-2024, Available :http://www.jetir.org/papers/JETIR2410499.pdf

"A Brief Review On Pharmaceutical Cocrystals: Advances In Methods Of Preparation And Formulation-Based Aspect ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 10, page no. ppe857-e865, October-2024, Available at : http://www.jetir.org/papers/JETIR2410499.pdf