• Amit Kumar Tiwari
• Chidanand
• Poonam
• Kedarsing
• Sharan Gouda

Oral route is the most oldest and convenient route for the administration of therapeutic agents because of low cost of therapy and ease of administration leads to higher level of patient compliance. The aim of this investigation was to develop and evaluate extended release drug delivery system for Bumetanide and comparing with marketed product. Hydrophilic matrix based tablets using different concentrations of different grades of HPMC i.e. K4M, K15M , K100M, Metalose 60 SH-50 and Xanthum gum were used to develop twelve formulations (F1 – F12) using direct compression technique and were subjected to physicochemical and in vitro dissolution studies by comparing with marketed product. The net content of Bumetanide was 80mg and the total tablet weight was 265mg. he F12 formulation was compared with the marketed product for drug release pattern and was matched using similarity factor (f2) which showed that formulation F12 performed similar to the marketed product therapeutically.

Bumetanide, Metalose 60 SH-50 and Xanthum gum

"FORMULATION AND EVALUATION OF EXTENDED RELEASE OF BUMETANIDE TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 10, page no.f352-f363, October-2024, Available :http://www.jetir.org/papers/JETIR2410531.pdf

"FORMULATION AND EVALUATION OF EXTENDED RELEASE OF BUMETANIDE TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 10, page no. ppf352-f363, October-2024, Available at : http://www.jetir.org/papers/JETIR2410531.pdf