• Amaan Sheikh
• Shubham Wankhede
• Shivshankar Mhaske

Abstract:- Diabetes mellitus, a chronic metabolic disorder, poses significant health challenges worldwide, necessitating innovative treatment strategies. This study explores a novel approach combining ethosome-loaded repaglinide with microneedling to enhance the drug's transdermal delivery and therapeutic efficacy. Ethosomes, lipid-based carriers characterized by their enhanced permeability, are employed to encapsulate repaglinide, a widely used antidiabetic agent. The microneedling technique is introduced to create microchannels in the skin, facilitating deeper penetration of ethosomes and improving bioavailability. In vitro and in vivo evaluations demonstrate that this combination significantly enhances the drug's absorption and pharmacological effect compared to conventional delivery methods. This dual approach not only optimizes repaglinide delivery but also holds promise for improving patient compliance by minimizing systemic side effects and enabling localized treatment.

Ethosome • Repaglinide • Microneedling • Diabetes mellitus • Transdermal delivery • Drug encapsulation • Enhanced permeability • Pharmacokinetics • Bioavailability • Innovative therapy • Chronic metabolic disorder • Patient compliance • Localized treatment • Skin microchannels • Novel drug delivery system.

"Ethosome Loaded Repaglinide and Microneedling , Novel approach for diabetes mellitus Treatment ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 10, page no.f595-f603, October-2024, Available :http://www.jetir.org/papers/JETIR2410561.pdf

"Ethosome Loaded Repaglinide and Microneedling , Novel approach for diabetes mellitus Treatment ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 10, page no. ppf595-f603, October-2024, Available at : http://www.jetir.org/papers/JETIR2410561.pdf