• D Pavitra
• M Gayatri Devi
• K Srinu

Sterile pharmaceutical preparations, such as sterile powders and injections, are crucial in clinical medicine for the treatment and management of various health conditions, especially when rapid drug action is needed. The formulation of these products requires stringent procedures and technologies to ensure safety, efficacy, and stability. Formulating injections involves developing solutions, suspensions, or emulsions that remain stable under sterilization conditions. Solvents, co-solvents, surfactants, and chelating agents are chosen to enhance solubility and maintain the drug’s stability. Sterile powders are typically prepared by lyophilization (freeze-drying), spray drying, or sterile crystallization of active pharmaceutical ingredients (APIs) that are sensitive to liquid degradation. The choice of excipients, such as bulking agents, buffering agents, stabilizers, and tonicity adjusters, plays a significant role in maintaining the physical and chemical stability of the drug. Key considerations in the development process include optimizing the pH, controlling moisture content, and ensuring uniform particle size to facilitate reconstitution and administration.This abstract outlines the essential principles and strategies involved in the development of sterile powders and injectable dosage forms.

sterile, parenterals, stability, lyophilization

"OVERVIEW ON FORMULATION OF INJECTIONS AND STERILE POWDERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 11, page no.a691-a702, November-2024, Available :http://www.jetir.org/papers/JETIR2411071.pdf

"OVERVIEW ON FORMULATION OF INJECTIONS AND STERILE POWDERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 11, page no. ppa691-a702, November-2024, Available at : http://www.jetir.org/papers/JETIR2411071.pdf