• Lava S Gowda
• Bharathi Arali
• Uma Patil
• Anitha M R

: Spironolactone (SPL) is a commonly prescribed potassium-sparing diuretic that acts as an aldosterone antagonist and belongs to the BCS class II. It undergoes solubility testing in a non-volatile solvent and is formulated as a liquisolid. The liquisolid formulation's dissolving properties contrast with regular tablets and pure drugs. The liquisolid compacts were developed using three non-volatile solvents (including PEG400, propylene glycol, and glycerin), three carrier materials (lactose monohydrate, mannitol, and microcrystalline cellulose pH 102), and one coating material (aerosil 200) with an R-value of 15. FT-IR method was used to evaluate the compatibility of spironolactone with the liquisolid excipients. The findings showed that most liquisolid compacts satisfied the Indian Pharmacopeia's (IP) requirements. By reaching 50 mg/ml, the solubility research showed enhanced solubility in PEG400. When spironolactone preparations were evaluated utilizing IP testing techniques, it was demonstrated that formulations using PEG400 as the non-volatile solvent, lactose monohydrate (carrier), and aerosil 200 (coating material) respectively, had a much higher dissolving rate. Only 18.32% of the pure drug and 74.81% of the traditional tablets were released in the same hour as 94.50% in this formulation. In conclusion, the use of non-volatile solvents in spironolactone liquisolid compacts enhances both the drug's solubility and its dissolution rate.

Spironolactone, Liquisolid compact technique, PEG400, Propylene glycol, and Glycerine.

"IMPROVING SOLUBILITY AND DISSOLUTION PROPERTIES OF SPIRONOLACTONE USING NON-VOLATILE SOLVENT BY LIQUISOLID COMPACT TECHNIQUE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 11, page no.b231-b236, November-2024, Available :http://www.jetir.org/papers/JETIR2411125.pdf

"IMPROVING SOLUBILITY AND DISSOLUTION PROPERTIES OF SPIRONOLACTONE USING NON-VOLATILE SOLVENT BY LIQUISOLID COMPACT TECHNIQUE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 11, page no. ppb231-b236, November-2024, Available at : http://www.jetir.org/papers/JETIR2411125.pdf