• G.Harshitha
• Dr.K.V. Ratnamala

Solid lipid nanoparticles are at the top most priority in this rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other various sciences. Due to their unique size-dependent property and lipid nanoparticles offer the possibility to develop new therapeutics. The ability of incorporating drugs into nanocarriers offers a new prototype in the drug targeting .Hence, solid lipid nanoparticles hold great ability for reaching the goal of controlled and site specific drug delivery and hence have attractive and wide attention of researchers .This review presents a wide range of treatment of solid lipid nanoparticles discussing their possible remedies. The different types of nanocarriers which were based in solid lipid like solid lipid nanoparticles, nanostructure lipid carriers, different lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are been described. Appropriate analytical techniques for the characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are been highlighted. Aspects of solid lipid nanoparticles route of administrations and their biodistribution are also been incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases.

Solid lipid nanoparticles are at the top most priority in this rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other various sciences. Due to their unique size-dependent property and lipid nanoparticles offer the possibility to develop new therapeutics. The ability of incorporating drugs into nanocarriers offers a new prototype in the drug targeting .Hence, solid lipid nanoparticles hold great ability for reaching the goal of controlled and site specific drug delivery and hence have attractive and wide attention of researchers .This review presents a wide range of treatment of solid lipid nanoparticles discussing their possible remedies. The different types of nanocarriers which were based in solid lipid like solid lipid nanoparticles, nanostructure lipid carriers, different lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are been described. Appropriate analytical techniques for the characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are been highlighted. Aspects of solid lipid nanoparticles route of administrations and their biodistribution are also been incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases.

"SOLID LIPID NANOPARTICLES A NOVEL DRUG DELIVERY SYTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 11, page no.c168-c179, November-2024, Available :http://www.jetir.org/papers/JETIR2411222.pdf

"SOLID LIPID NANOPARTICLES A NOVEL DRUG DELIVERY SYTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 11, page no. ppc168-c179, November-2024, Available at : http://www.jetir.org/papers/JETIR2411222.pdf