• Jyoti Patel
• Ankita Shukla
• Dr Naveen Gupta

The design, development, and optimization of an emulgel formulation containing Clove Oil and Naftifine Hydrochloride (HCl) were explored to improve the topical delivery and efficacy of the active ingredients in the treatment of fungal infections. Clove oil, known for its potent antifungal and analgesic properties, was combined with Naftifine HCl, a well-established antifungal agent, to enhance the therapeutic effects. The emulgel, a hybrid system combining the characteristics of both emulsion and gel, was developed to provide a stable, non-greasy, and easily applicable formulation with enhanced skin penetration. Various factors, including the choice of gelling agent, emulsifying agent, and concentration of active ingredients, were optimized to ensure desired stability, viscosity, spreadability, and drug release profile.Preliminary formulations were developed using different gelling agents such as Carbopol and Hydroxypropyl Methylcellulose (HPMC) in combination with emulsifiers like Tween 80. The physical properties of the formulations were assessed, including appearance, pH, rheological behavior, and in-vitro drug release. The stability of the emulgel was evaluated under different storage conditions to ensure long-term effectiveness and minimal degradation of the active components. In-vitro antifungal activity was tested using standard fungal strains, and the results indicated a synergistic effect between Clove Oil and Naftifine HCl, significantly enhancing antifungal activity compared to individual components. The optimized emulgel formulation demonstrated excellent spreadability, good stability, and superior efficacy, making it a promising candidate for topical treatment of fungal infections.

Naftifine, Clove oil, Emulgel, Anti-fungal, Optimization.

"DESIGN, DEVELOPMENT AND OPTIMIZATION OF EMULGEL CONTAING CLOVE OIL AND NAFTIFINE HCL. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 11, page no.d204-d216, November-2024, Available :http://www.jetir.org/papers/JETIR2411325.pdf

"DESIGN, DEVELOPMENT AND OPTIMIZATION OF EMULGEL CONTAING CLOVE OIL AND NAFTIFINE HCL. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 11, page no. ppd204-d216, November-2024, Available at : http://www.jetir.org/papers/JETIR2411325.pdf