• Rohit Kumar Dwivedi
• Dr. Praveen Kumar Ashok
• Ms. Arati Tamta
• Dr. Divyanshi Rastogi

In order to determine the amounts of cilnidipine and lisinopril dihydrate, the Dual Wavelength Spectroscopic approach that was proposed was successfully utilized. The method that was created was verified in accordance with ICH Q2 (R1) without any deviations, and based on the findings, it was determined that the current method has the potential to be utilized for the routine examination of raw materials as well as in the formulation of pharmaceuticals. According to the findings of the linearity investigation, the suggested approach was able to produce linear results throughout the concentration range of 4–24 and 10–60 μg/mL for lisinopril dihydrate and cilnidipine, respectively. It was determined that the proposed method was accurate based on the findings of the precision data and the low levels of the relative standard deviation (RSD). Both the LOD and LOQ values for cilnidipine and lisinopril dihydrate were determined and established. It was discovered that the recovery for lisinopril dihydrate was 98.82%, and the recovery for cilnidipine was 100.24%. The low values of the relative standard deviation (RSD) demonstrate that the procedure was accurate within the range that was defined. The suggested approach was found to be linear, sensitive, exact, and accurate for the simultaneous estimation of lisinopril dihydrate and cilnidipine in bulk and pharmaceutical formulations. This conclusion was reached as a consequence of the successful completion of the validation research and the findings that were discovered.

cilnidipine,lisinopril dihydrate

"Development and validation of analytical methods for estimation of calcium channel blocker", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 11, page no.f793-f805, November-2024, Available :http://www.jetir.org/papers/JETIR2411590.pdf

"Development and validation of analytical methods for estimation of calcium channel blocker", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 11, page no. ppf793-f805, November-2024, Available at : http://www.jetir.org/papers/JETIR2411590.pdf