• Akshay S. Sidam
• Piyush G. Paighan
• Komal V. Shende
• Dr. Nilesh O. Chachda
• Khushi M. Kongre

Oxymetazoline HCL is a nasal decongestant commonly used to relieve nasal congestion caused by colds, allergies, or sinusitis. Oxymetazoline, an alpha-adrenergic agonist, reduces edema and makes breathing easier by narrowing blood vessels in the nasal passages. It acts rapidly to provide temporary relief and is usually applied as a nasal spray. Although it works, using it for longer than three days can cause rebound congestion, also known as rhinitis medicamentosa, in which the congestion gets worse when you stop using it. When taken as directed, it is usually well tolerated, though it may have modest side effects such transient dryness or irritation of the nose. This selective alpha-adrenergic agonist is frequently applied topically to relieve congestion. It reduces nasal congestion and edema by narrowing blood vessels in the nasal mucosa. This substance is frequently present in over-the-counter medications used to alleviate sinus and nasal congestion brought on by colds or allergies. Although generally helpful usage over time may result in rebound congestion, also referred to as rhinitis medicamentosa. According to research, oxymetazoline's vasoconstrictive effects are a result of its stimulation of alpha-1 and alpha-2 adrenergic receptors. When used as prescribed, clinical research has shown that it is both safe and effective.

Nasal congestion, Adrenergic alpha-1 receptor agonists, adrenergic receptor agonists, adrenoreceptors, oxymetazoline

"“A Comprehensive Review on Oxymetazoline Hydrochloride as Nasal Spray”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.a598-a612, December-2024, Available :http://www.jetir.org/papers/JETIR2412054.pdf

"“A Comprehensive Review on Oxymetazoline Hydrochloride as Nasal Spray”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppa598-a612, December-2024, Available at : http://www.jetir.org/papers/JETIR2412054.pdf