• Shrestha Sarkar
• Shiwani Saini
• Neetu Rajpoot
• Shiba S Morris

Abstract- Depression is a chronic mental disorder that affects up to 20% of people worldwide. A piperazine is a six-membered heterocyclic ring that has two opposing nitrogen atoms and is used for various therapeutic activities including depression. The phenyl piperazine derivatives have a potent antidepressant effect. They showed great potential in in silico studies and proved to be good mono-amino oxidase inhibitors. In this study, various phenyl piperazine derivatives were designed and docked at the respective active sites of the receptor 2z5x using various docking softwares ( autodock vina, pyrax etc.) and was evaluated for their drug likeness (using the software SwissADME) and bioactivity scores (using the software Molinspiration). The derivatives showed good docking and bioactivity scores and displayed drug-like characteristics, including blood-brain barrier permeability. Thus, these derivatives can be further synthesized and carried out for in vivo evaluation to show potent anti-depressant activity.

Keywords- Docking, Piperazine, Depression, Drug design

"In-silico Studies of Phenyl Piperazine Derivatives Against Depression", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.b309-b321, December-2024, Available :http://www.jetir.org/papers/JETIR2412126.pdf

"In-silico Studies of Phenyl Piperazine Derivatives Against Depression", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppb309-b321, December-2024, Available at : http://www.jetir.org/papers/JETIR2412126.pdf