• Mr.Chabukswar Avinash.S
• Ms.Dusane Gaytri.V
• Dr. Rajendra.M kawade

Apoptosis, survival, proliferation, invasion, and other biological characteristics of the malignant phenotype are all influenced by pathophysiological interactions with microenvironmental components in multiple myeloma, a B-cell lineage cancer in which neoplastic plasma cells proliferate in the bone marrow. Multiple myeloma (MM) is still incurable, even though patient survival has improved over the past 20 years due to the development of a safer and more effective class of medications (such as immunomodulators, proteasome inhibitors, and monoclonal antibodies). Tumour plasma cells settle and proliferate in the complex structure known as the bone marrow microenvironment, which is made up of cells, extracellular matrix (ECM) proteins, and cytokines. Because tumour plasma cell-induced alteration is essential for creating a “permissive” environment that promotes MM plasma cell proliferation, migration, survival, and treatment resistance, the bone marrow (BM) microenvironment plays a critical role in the course of MM illness. The multiple myeloma microenvironment’s “activated phenotype” contributes to plasma cell treatment resistance as well as proliferation and dissemination. Autophagy, transcriptional rewiring, stress-managing pathways, and dysregulation of non-coding RNAs are the mechanisms via which bone marrow stromal cells create drug resistance in plasma cells. These mechanisms serve as new targets for the growing arsenal of anti-MM treatment options.

Multiple myeloma; biological models; bone marrow; 3D printing, plasma cells.

"Advancements and Challenges in Multiple Myeloma: Insights into Bone Marrow Pathophysiology and Therapeutic Strategies", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.b334-b345, December-2024, Available :http://www.jetir.org/papers/JETIR2412129.pdf

"Advancements and Challenges in Multiple Myeloma: Insights into Bone Marrow Pathophysiology and Therapeutic Strategies", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppb334-b345, December-2024, Available at : http://www.jetir.org/papers/JETIR2412129.pdf