• Mistry Saurab (Corresponding author)
• Minocha Dr. Pramod Kumar
• Kothwala Dr. Deveshkumar
• Pandya Kamna
• Dave Arpit and Shah Hrishikesh

This study evaluated the thrombogenicity and biocompatibility of the WALL-NUT™ left atrial appendage (LAA) occluder device in three animals (porcine model). No device-related thrombogenic events, embolization, or adverse outcomes were observed throughout the study period. Transesophageal echocardiography (TEE) revealed stable device positioning without evidence of thrombus formation, device migration, or pericardial effusion. Clinical assessments showed no signs of morbidity, abnormal weight loss, or significant changes in hematology or clinical chemistry between pre and post-implantation. Histopathological evaluations indicated a mild inflammatory response around the implant, with progressive endothelialization of the device surface. Two animals exhibited up to the 75% endothelial coverage, while one achieved complete coverage by 90 days. The presence of inflammatory cells was noted, but without escalation of the response over time. These findings demonstrate the LAA occluder’s strong safety profile and biocompatibility, supporting its potential for clinical application in preventing stroke in patients with atrial fibrillation. Future studies with longer follow-up are recommended to confirm long-term efficacy.

WALL-NUT™ Left atrial appendage (LAA) occluder Device, Porcine Model, Safety Evaluation, Performance Assessment, radiography and angiographic findings, Histopathological Findings.

""Evaluation Of Safety And Performance Of WALL-NUT™ Left Atrial Appendage Occluder System (LAAOD): A Porcine Model Analysis Over Multiple Time Points"", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.f178-f201, December-2024, Available :http://www.jetir.org/papers/JETIR2412522.pdf

""Evaluation Of Safety And Performance Of WALL-NUT™ Left Atrial Appendage Occluder System (LAAOD): A Porcine Model Analysis Over Multiple Time Points"", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppf178-f201, December-2024, Available at : http://www.jetir.org/papers/JETIR2412522.pdf