• Shivani P Chavan
• Shivali M Khandarkar
• Aditya V Palandurkar
• Sanjana R Bali
• Dr. Shivshankar Mhaske

Oleogels are a promising class of gel-like materials formed by dispersing oils or lipids into a gel network using gelling agents. As drug delivery systems, oleogels offer significant advantages in terms of biocompatibility, stability, and controlled drug release, making them highly versatile for a wide range of pharmaceutical applications. Oleogels can be tailored for various delivery routes, including topical, transdermal, and controlled-release formulations, offering unique benefits in drug absorption, patient compliance, and therapeutic efficacy.The structure of oleogels, composed of natural or synthetic oils combined with gelling agents such as fatty acids, surfactants, or polymers, provides excellent stability and high drug-loading capacity. These systems can encapsulate both hydrophobic and hydrophilic drugs, making them suitable for a broad spectrum of therapeutic agents. Oleogels also exhibit non-greasy textures, improved skin permeability, and prolonged release profiles, which are especially beneficial for transdermal drug delivery.The versatility of oleogels lies in their tunable properties, including viscosity, gel strength, and drug release rate, which can be customized to optimize the delivery of specific drugs. This adaptability makes oleogels suitable for diverse applications, ranging from anti-inflammatory creams to more complex drug formulations for chronic diseases.In conclusion, oleogels are a highly versatile and innovative drug delivery platform with the potential to enhance drug bioavailability, improve patient adherence, and offer more effective treatments across various pharmaceutical fields.Their ability to deliver a wide range of drugs through controlled and sustained release positions oleogels as a promising solution in modern drug delivery systems.

oleogelators, drug delivery, stability of oleogels.

"OLEOGEL: VERSATILE NOVEL SEMI-SOLID SYSTEM IN PHARMACEUTICALS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.f365-f384, December-2024, Available :http://www.jetir.org/papers/JETIR2412541.pdf

"OLEOGEL: VERSATILE NOVEL SEMI-SOLID SYSTEM IN PHARMACEUTICALS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppf365-f384, December-2024, Available at : http://www.jetir.org/papers/JETIR2412541.pdf