• Shivali M Khandarkar
• Shivani P Chavan
• Aditya V Palandurkar,
• Sanjana R Bali
• Dr. Shivshankar Mhaske

Nanostructured Lipid Carriers (NLCs) are advanced drug delivery systems designed to overcome the limitations of conventional drug delivery methods, including poor solubility, instability, and inefficient bioavailability. NLCs are second-generation lipid nanoparticles, composed of a blend of solid and liquid lipids stabilized by surfactants. This unique composition enables the formation of a matrix with increased drug loading capacity, enhanced stability, and controlled drug release properties. The biocompatibility and biodegradability of lipids used in NLCs make them a promising carrier for a wide range of therapeutic agents, including hydrophilic and hydrophobic drugs, peptides, and even genetic materials. Their small particle size, typically in the nanometer range, facilitates improved penetration across biological membranes, allowing for targeted and sustained drug delivery. NLCs also offer advantages in protecting sensitive drugs from degradation and reducing adverse side effects. Recent advancements have demonstrated the versatility of NLCs in various applications, including oral, topical, transdermal, pulmonary and parenteral drug delivery. Additionally, NLCs have shown potential in addressing challenges in cancer therapy, central nervous system disorders, and antimicrobial treatments. Emerging research emphasizes their role in enhancing bioavailability and patient compliance, particularly in challenging therapeutic scenarios. This review explores the structure, preparation techniques, advantages, and applications of NLCs in modern pharmaceutical sciences, highlighting their role as a novel and efficient drug delivery tool with significant potential to revolutionize personalized medicine and therapeutic outcome.

NLC , nanoparticles , solid lipid nanoparticles

"NANOSTRUCTURED LIPID CARRIER - A LIPID BASED NOVEL DRUG DELIEVERY TOOL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.g662-g678, December-2024, Available :http://www.jetir.org/papers/JETIR2412675.pdf

"NANOSTRUCTURED LIPID CARRIER - A LIPID BASED NOVEL DRUG DELIEVERY TOOL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppg662-g678, December-2024, Available at : http://www.jetir.org/papers/JETIR2412675.pdf