• Tejinder Kaur
• R. K. Dhawan

Background: Thyroid hormone regulates a wide range of genes after its activation from the prohormone, thyroxine (T4), to the active form, triiodothyronine (T3). The signaling pathway is complex and highly regulated due to the expression of cell and tissue-specific thyroid hormone transporters, multiple thyroid hormone receptor (TR) isoforms, and interactions with corepressors and coactivators. Furthermore, in many cases, thyroid signals are involved in cross-talk with a range of other signaling pathways. Materials & Methods: The study conducted on a total of 20 participants in which, 10 samples were healthy and 10 samples were lies in male category and 10 samples were lies in female category. The lipid profile was assessed using standard methodologies. Statistical analysis was performed using the GraphPad Prism9 stat® Software. Analysis of data was done using one-way ANOVA employing Tukey’s test, after analysis. p<0.05 was found to be statistically significant. Results: In our study population 45% belonged to Grade I obesity, while 19% Grade II obesity and the remaining 36% were found to be non- obese. A statistically significant difference was observed in Triglyceride and HDL cholesterol levels (p <0.05). Conclusion: The present study revealed that the Cholesterol level was observed significantly higher in Hypothyroid Males as compared to Hypothyroid Females. The prevalence of LDL, TG, and VLDL were seen higher in Hypothyroid Females in comparison to Hypothyroid Males. Increase in prevalence of the Metabolic Syndrome was higher in women than in men. This might be driven by the constant rise in Obesity in women. Thyroid Hormone might affect lipid metabolism and numerous studies have found that lipid levels increase as TSH levels increase

Thyroxine, Triiodothyronine, Thyroid Hormone.

"UNRAVELING THE STUDY OF DYSLIPEDEMIA IN HYPOTHYRODISM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.g743-g748, December-2024, Available :http://www.jetir.org/papers/JETIR2412682.pdf

"UNRAVELING THE STUDY OF DYSLIPEDEMIA IN HYPOTHYRODISM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppg743-g748, December-2024, Available at : http://www.jetir.org/papers/JETIR2412682.pdf