• Suhael Ashraf
• Dr Md Shamsuddin Munawar

The present study was carried out to assess the hepatoprotective activitiy of aqueous extract of aerial part extract of Cassia Sophera (Linn) (AQEACS) in rats. Preliminary phytochemical studies revealed the presence of phytoconstituents like carbohydrates, amino acids, fixed oils, fats, Ascorbic acid, glycosides and sterols. Toxicity profile of the crude extract was conducted in albino mice by following OECD Guideline No-425. It was found that even at 2g/kg the extract is safer to be used which was confirmed in mice which have not shown any mortality. The hepatoprotective activity was studied in ranitidine induced hepatotoxic animal models in rats. The biochemical parameters studied were ALT, AST, ALP, BILD, BILT, ALB, PRO, CHO and TRG levels in serum. Prevention of elevation in biochemical parameter levels like ALT, AST, ALP, BILD, BILT, CHO and TRG and increase in ALB, PRO in serum after treatment with the extracts confirmed that hepatoprotective effect of these extracts against ranitidine induced liver injury. Drug induced hepatotoxicity was significantly prevented by pretreatment with the extract.

Hepatoprotective, OECD, ranitidine, Cassia Sophera

"Effect of Aerial Part Extract of Cassia Sophera (Linn) on Ranitidine induced Hepatotoxicity in Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.g768-g770, December-2024, Available :http://www.jetir.org/papers/JETIR2412686.pdf

"Effect of Aerial Part Extract of Cassia Sophera (Linn) on Ranitidine induced Hepatotoxicity in Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppg768-g770, December-2024, Available at : http://www.jetir.org/papers/JETIR2412686.pdf