• Monika Malviya
• Jagdish Chandra Rathi
• Shivani Suryavanshi

The main objective of present work is pharmacological evaluation of anti-Pyretic activity of santalum album leaves extract in wistar rats. Phytochemical analysis of methanolic extract of Santalum album showed the presence of alkaloids, carbohydrate, saponins, glycoside and saponin. Quantitative phytochemical assay was performed by calculating total phenolic content (TPC) and total flavonoid content (TFC). The TPC was calculated with respect to gallic acid (standard) and TFC was then calculated with respect to rutin taken as standard. DPPH radical scavenging activity of Santalum album extract exhibited percent inhibition 60.28% and its IC 50value was found to be 48.74μg/ml. Ascorbic was used as a reference compound which exhibited percent inhibition 85.67% and showed IC 50 value of 21.77μg/ml. In the acute toxicity study, no signs of toxicity were found upto the dose of 2000 mg/kg body weight. Hence 1/10th and 1/5th doses i.e. 100 mg/kg and 200 mg/kg have been fixed for study. Brewer’s yeast was used to induce fever in albino rats. Fever was recorded 18 hrs after yeast injection since yeast takes a total of about 18 hrs to cause the elevation of body temperature. Subcutaneous injection of Brewer’s yeast induces pyrexia by increasing the synthesis of prostaglandin. It is considered as a useful test for the screening of plants materials as well as synthetic drugs for their antipyretic effect. The inhibition of prostaglandin synthesis could is the possible mechanism of antipyretic action as that of paracetamol and the inhibition of prostaglandin can be achieved by blocking the cyclo-oxygenase enzyme activity. Thus it can be postulated that Santalum album, contained pharmacologically active principles that interfere with the release of prostaglandins. After four hours of the test period, the methanolic extract of Santalum album produced appreciable antipyretic activity against brewer’s yeast induced pyrexia in albino rat. It was revealed that the extract showed dose dependent antipyretic activity. It was revealed that the extract showed dose dependent antipyretic activity since 100mg/kg dose of test solution is considered as a slow acting compared to the higher dose preparation . This effect may be related to the extract’s analgesic and anti-inflammatory activity. There is evidence to believe that this plant contains compounds acting as NSAI drugs.

Antipyretic, Medicines, Pyrexia, Extraction, Assay

"PHARMACOLOGICAL EVALUATION OF ANTI-PYRETIC ACTIVITY OF SANTALUM ALBUM LEAVES EXTRACT IN WISTAR RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.h278-h291, December-2024, Available :http://www.jetir.org/papers/JETIR2412731.pdf

"PHARMACOLOGICAL EVALUATION OF ANTI-PYRETIC ACTIVITY OF SANTALUM ALBUM LEAVES EXTRACT IN WISTAR RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. pph278-h291, December-2024, Available at : http://www.jetir.org/papers/JETIR2412731.pdf