• Angsuman Das Chaudhuri
• Anirban Majumder
• Sounik Manna
• Rathindranath Baral
• Sujata Maiti Choudhury

Geraniol, a naturally occurring monoterpenoid alcohol, has garnered attention for its diverse biological activities, including antioxidant and cytotoxic effects. However, its poor solubility and bioavailability often limit its therapeutic potential. To overcome these challenges, we present a bioconjugate approach that integrates geraniol with dextran and folic acid to form nanoparticles, enhancing the compound's stability and biological efficacy. The geraniol-dextran-folic acid nanoparticles (GER-DEX-F NPs) were synthesized using a simple, cost-effective method. The hydrodynamic diameter of GER-DEX-F NPs was 201.64 nm with a polydispersity index (PDI) of 0.321 and spherical in structure. In vitro studies demonstrated that GER-DEX-F NPs exhibited a significantly enhanced cytotoxic effect on cancer cells, as compared to free geraniol, while maintaining low toxicity towards normal cells. Furthermore, the nanoparticles showed marked improvement in nitric oxide scavenging activity, diphenyl-2-2picrylhydrazine (DPPH) scavenging activity, hydroxyl radical scavenging activity, hypochlorous acid scavenging activity, lipid peroxidation scavenging activity, superoxide anion scavenging activity and peroxynitrite scavenging activity, as evidenced by increased scavenging of reactive oxygen species (ROS) and enhanced cellular antioxidant enzyme activity. This study highlights the potential of GER-DEX-F NPs as a biocompatible, promising nanotherapeutic platform for cancer treatment, with dual mechanisms of cytotoxicity and remarkable antioxidant activity, opening avenues for further clinical exploration and development in the treatment of oxidative stress-related diseases.

geraniol, dextran, folic acid, nanoparticles, antioxidant, anti-cancer

"Geraniol-Dextran-Folic Acid Nanoconjugate: Synthesis, In-vitro Cytotoxicity and Antioxidant Efficacy for Targeted Therapeutic Applications", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.a139-a146, January-2025, Available :http://www.jetir.org/papers/JETIR2501019.pdf

"Geraniol-Dextran-Folic Acid Nanoconjugate: Synthesis, In-vitro Cytotoxicity and Antioxidant Efficacy for Targeted Therapeutic Applications", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppa139-a146, January-2025, Available at : http://www.jetir.org/papers/JETIR2501019.pdf