• Soumitra Mandal

The advancement of immunotherapy has significantly transformed modern medical practices, with gold nanoparticles (AuNPs) emerging as a groundbreaking platform for vaccine innovation. Characterized by their exceptional physicochemical properties- such as biocompatibility, adjustable size, and surface functionalization- AuNPs offer remarkable potential in optimizing antigen delivery, preserving vaccine stability, and amplifying immune responses. This article provides a comprehensive analysis of the role of gold nanoparticles in vaccine technology, delving into their underlying mechanisms, distinct advantages over traditional systems, and cutting-edge progress in both preclinical and clinical research. Additionally, it examines the challenges and prospective pathways for AuNP-based vaccines as a pivotal evolution in the field of immunotherapy.

Gold nanoparticles, Vaccines, Immunotherapy, Nanotechnology, Antigen delivery, Cancer immunotherapy, Infectious diseases.

"Gold Nanoparticle-Based Vaccines: A New Frontier in Immunotherapy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.a959-a974, January-2025, Available :http://www.jetir.org/papers/JETIR2501122.pdf

"Gold Nanoparticle-Based Vaccines: A New Frontier in Immunotherapy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppa959-a974, January-2025, Available at : http://www.jetir.org/papers/JETIR2501122.pdf