• Dr Krishnaphanisri P

The objective of the present review article was to develop an innovative, simple, and economic method for estimation of RALTEGRAVIR by HPLC. The chromatographic conditions were performed on Symmetry Develosil ODS HG-5 RP C18, 5m, 15cmx4.6mm i.d. as stationary phase and mobile phase was prepared with a mixture of Phosphate buffer(pH=3.0): Methanol with 30:70, flow 1.0 ml/min, with Injection Volume 10µl, at detection wavelength 246 nm and run time at 5.0 min. The analytical method is valid for estimation of Raltegravir over a range of 20 µg/ml–70 µg/ml. The results of system suitability test, linearity, precision and accuracy, robustness, specificity, LOD and LOQ and stabilities presented in this report are within the acceptance range. A specific, sensitive, economic method estimation of Raltegravir has been developed based on ICH Guidelines with bulk and dosage forms.

Raltegravir, HPLC, Method Development, ICH, Validation, Accuracy, Precision

"A REVIEW- ON HPLC METHOD FOR ESTIMATION OF RALTEGRAVIR", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.c105-c113, January-2025, Available :http://www.jetir.org/papers/JETIR2501216.pdf

"A REVIEW- ON HPLC METHOD FOR ESTIMATION OF RALTEGRAVIR", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppc105-c113, January-2025, Available at : http://www.jetir.org/papers/JETIR2501216.pdf