• B. Jayashankar
• Sathish Kumar B N

Series of Bis(heterocycle) bearing isoxazoline in combination of imidazole and isoxazole has been synthesized via 1,3-dipolar cycloaddition reactions of N- (substituted) methyl-imidazole nitrile oxides with different dipolarophiles. All the newly synthesized compounds were screened for their anti-inflammatory and analgesic activity and were compared with the standard drugs. The compounds exhibited excellent anti- inflammatory and analgesic activity. Out of the compounds studied, compounds 7e and 7f showed significant activity comparable to the standard drugs Ibuprofen and Aspirin at the same dose.

Anti-inflammatory, analgesic, N-(substituted)imidazole aldehyde, chloramine-T.

"Synthesis and Evaluation of Anti-inflammatory and Analgesic activity of Isoxazoline Bearing Bis(heterocycle)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.c123-c130, January-2025, Available :http://www.jetir.org/papers/JETIR2501218.pdf

"Synthesis and Evaluation of Anti-inflammatory and Analgesic activity of Isoxazoline Bearing Bis(heterocycle)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppc123-c130, January-2025, Available at : http://www.jetir.org/papers/JETIR2501218.pdf