• Gurpreet Singh
• Amisha Gautam
• Pankaj Kumar
• Shivani Pathania
• Ankush Uppal

Hepatotoxins, which can originate from chemicals, pharmaceutical medications, nutritional supplements, and medicinal plants, are what cause hepatotoxicity, or injury to the liver. Notably, many medicinal plants are used to treat illness, especially in traditional medical systems like Traditional Chinese Medicine and Ayurveda. For millennia, these medical methods have been used to treat a variety of illnesses. While some medicinal herbs cause hepatotoxicity, others act as hepatoprotectors against liver injury. Research scientists can now examine the drug metabolic pathways of these phytopharmaceuticals and establish a causal link between medicinal plants and their pharmacological effects on the human liver, either as a hepatoprotector or a causative agent for hepatotoxicity, thanks to recent advancements in instrumentation and knowledge of active components. Oxidation, reduction, hydration, hydrolysis, condensation, conjugation, and isomerization are some of the ways that chemicals are metabolized by the human liver. When these processes are disrupted, hepatotoxicity can result, which can cause cirrhosis, Hepatitis C, and liver cancer, respectively. Globally, these illnesses are the cause of greater death rates. The current research emphasizes the difficulties faced by phytopharmaceuticals as well as a variety of hepatoprotective and hepatotoxic plants. The article also highlights a number of substances that have been shown to cause hepatotoxicity, including pharmaceutical chemicals, industrial poisons, and bioactives from medicinal plants. For upcoming natural product-based drug discovery, the study suggests perspectives and advantageous medicinal plants that can aid in the identification of natural hepatoprotective agents.

Hepatotoxicity

"Hepatotoxicity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.c184-c188, January-2025, Available :http://www.jetir.org/papers/JETIR2501222.pdf

"Hepatotoxicity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppc184-c188, January-2025, Available at : http://www.jetir.org/papers/JETIR2501222.pdf