• Bellale Sneha Somnath
• Vansika
• Bavage Ashlesha Shivanand
• Torkade Vishal Mahadev
• Kiran C Rodage

Topical dosage forms play a pivotal role in drug delivery systems, offering localized treatment with reduced systemic side effects. This review explores the formulation, mechanism of action, advantages, and challenges associated with topical delivery systems such as creams, ointments, gels, lotions, patches, and foams. Key factors influencing their efficacy, including drug solubility, skin permeability, and the role of excipients, are discussed. Innovations such as nanotechnology-based topical systems and bio adhesive formulations are highlighted for their potential to enhance drug absorption and therapeutic outcomes. Challenges like skin irritation, variability in individual responses, and formulation stability are also addressed. Future perspectives emphasize the integration of advanced materials and delivery techniques to optimize patient outcomes. This comprehensive review aims to provide insights for researchers and healthcare professionals to advance the development of effective topical dosage forms.

Topical drug delivery, Dosage forms, Skin permeability , Creams, ointment, Gels ,Lotions, Transdermal patches Foams, Drug solubility • Excipients, Nanotechnology, Bioadhesive formulations • Skin irritation, Formulation stability, Localized treatment

"A Comprehensive Overview On Topical Dosage Form", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.d388-d400, January-2025, Available :http://www.jetir.org/papers/JETIR2501340.pdf

"A Comprehensive Overview On Topical Dosage Form", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppd388-d400, January-2025, Available at : http://www.jetir.org/papers/JETIR2501340.pdf