• Vibji MM
• Priyankar Bhooshan
• Souparna Madhavan

Hepatocellular carcinoma (HCC) is a major global health challenge, with a tumor microenvironment (TME) that plays a critical role in its progression. Among the TME components, the extracellular matrix (ECM) is integral to tumor development and immune modulation. ECM disorganization, characterized by changes in composition, stiffness, and architecture, is closely linked to immune cell infiltration, influencing tumor immune evasion and response to therapy. This review explores the relationship between ECM alterations and immune cell behavior in liver cancer, emphasizing the underlying mechanisms, profiling techniques, and clinical implications for therapeutic interventions.

"Association of Extracellular Matrix Disorganization with Immune Cell Infiltration in Liver Cancer: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.d493-d496, January-2025, Available :http://www.jetir.org/papers/JETIR2501357.pdf

"Association of Extracellular Matrix Disorganization with Immune Cell Infiltration in Liver Cancer: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppd493-d496, January-2025, Available at : http://www.jetir.org/papers/JETIR2501357.pdf