• Mrs. Reena Shinde
• Dr. Nilesh Khutle

Lipophilic drugs' low aqueous solubility and low bioavailability make oral delivery a significant challenge. The capacity of self-micro emulsifying drug delivery systems (SMEDDSs) to improve solubility and bioavailability has drawn attention to this issue. Numerous formulation-related factors, including droplet size, charge, oil/surfactant ratio, and surfactant concentration, affect how well the drug compound from the SMEDDS is absorbed orally. Ibuprofen a BCS class II drug with poor aqueous solubility was selected for development of SMEDDS. Ibuprofen's solubility in various oils, surfactants, and cosurfactants was examined. Capmul MCM (oil), Cremophore RH 40 (surfactant), and polyethylene glycol 400 (cosurfactant) were used to prepare the Ibuprofen SMEDDS. Several Evaluation parameters were performed to determine the optimization of Ibuprofen SMEDDS.

Ibuprofen, SMEDDS, Bioavailability, Capmul MCM, Cremophore RH 40, PEG 400.

"DEVELOPMENT, OPTIMIZATION AND CHARACTERIZATION OF SMEDDS OF POORLY SOLUBLE DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.g249-g257, January-2025, Available :http://www.jetir.org/papers/JETIR2501625.pdf

"DEVELOPMENT, OPTIMIZATION AND CHARACTERIZATION OF SMEDDS OF POORLY SOLUBLE DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppg249-g257, January-2025, Available at : http://www.jetir.org/papers/JETIR2501625.pdf