• Ms. Pratiksha S. Hiwarale
• Ms. Komal N. Jabalpure

Abstract: Vaccines play a critical role in mitigating the impact of infectious disease outbreaks, including COVID-19 and monkeypox, representing a landmark achievement in global scientific collaboration and rapid development. For both diseases, vaccines have undergone accelerated regulatory review processes by national regulatory authorities to facilitate timely approval and deployment. Equitable distribution of these vaccines remains a global priority, ensuring access across diverse populations. Simultaneously, robust safety surveillance systems must be urgently established within countries to comprehensively monitor vaccine safety. Such systems are essential for identifying and investigating adverse events of special interest (AESIs) and adverse events following immunization (AEFIs), enabling the assessment of any potential changes in the benefit-risk profiles of the vaccines for both COVID-19 and monkeypox. Additionally, these systems should anticipate and differentiate coincidental events that may be mistakenly linked to vaccination. Effective safety monitoring is vital to maintain public trust, inform regulatory decisions, and ensure the sustained success of global vaccination efforts against both pandemics and emerging threats such as monkeypox. IndexTerms - Adverse Events of Special Interest, Adverse Events Following Immunization, COVID-19, Monkeypox

Adverse Events of Special Interest, Adverse Events Following Immunization, COVID-19, Monkeypox ________________

"VACCINE SAFETY SURVEILLANCE IN PHARMACOVIGILANCE - A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 2, page no.b156-b165, February-2025, Available :http://www.jetir.org/papers/JETIR2502120.pdf

"VACCINE SAFETY SURVEILLANCE IN PHARMACOVIGILANCE - A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 2, page no. ppb156-b165, February-2025, Available at : http://www.jetir.org/papers/JETIR2502120.pdf