• Mr.Yadav Pratik Dhanlal
• Dr. Sagar S. Muley
• Dr. Sunil D. Kolhe
• Mr. Abhilash D. Waghmare

Phospholipids are used to make liposomes, also known as lipid vesicles. The hydrophilic interaction of polar heads with the aqueous environment and the hydrophobic interaction of phospholipid tails produces the vesicular structure of liposomes. Hydrophilic medications are easier to catch within the liposome core, whereas lipophilic drugs are easier to capture between the phospholipid layers of the liposomes. Depending on the properties of the drug and the method of manufacture, a medicine is stored into the liposomal core or in between the liposome's bilayers. Research is done on a wide range of liposome uses, such as targeted drug administration, big molecule transport, enhanced solubility, diagnostics, and medicine stability. Liposomes can be thought of as having developed from trasditional, long-circulating, immune-system-targeting liposomes to actively targeted liposomes that respond to stimuli based on their composition. Liposomes are highly biocompatible, biodegradable, and immunogenicity-free, made them most used nanocarriers for a hydrophilic and hydrophobic substances. Additionally, liposomes showed enhanced drug solubility and regulated distribution in addition to their ability to modify their surface for targeted, prolonged, and sustained release. For the treatment of a wide range of diseases, including infections by viruses, fungi, and cancer, several liposomal-based drug delivery techniques are currently clinically approved; numerous liposomes have reached the level of clinical testing.

Revolutionary changes, Methods of drug loading, classification, Evaluations, Liposomes as a vector in pharmaceutical product, Route of BBB for liposome transport, Liposomal methods for treating savior diseases.

"Recent Advances in Targeted and Stimuli-Responsive Liposomal Drug Delivery", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 2, page no.b423-b447, February-2025, Available :http://www.jetir.org/papers/JETIR2502141.pdf

"Recent Advances in Targeted and Stimuli-Responsive Liposomal Drug Delivery", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 2, page no. ppb423-b447, February-2025, Available at : http://www.jetir.org/papers/JETIR2502141.pdf