• Anjali S.Swami
• Dr.Nasheer S.Shaikh
• Yogesh Khamkar

The purpose of this study was to prepare nanolipospheres containing antifungal drug Luliconazole intended for topical skin delivery. Lipospheres are fat-based encapsulation system, developed for parenteral and topical drug delivery of bioactive compounds. Lipospheres consist of water dispersible solid microparticles, which have their diameter between 0.1 and 100mm. These are composed of a solid hydrophobic fat core (triglycerides) stabilized by a layer of phospholipid molecules embedded in their surface. The internal core contains the bioactive compound, dissolved or dispersed in the solid fat matrix. Lipospheres were prepared using different lipid cores and phospholipids coats by melt dispersion technique. Characterization was carried out through EE, FTIR, SEM, particle size analysis, PDI and zeta potential characterization was carried out. Luliconazole lipospheres are prepared by melt dispersion method which is one of the most used and best method for preparation of liposphere because it gives high entrapment efficiency with controlled particle size. The results showed that liposphere systems could entrap luliconazole at extremely high levels (93.1%). The particle size of liposphere systems was ideal for topical medication delivery. The preparation technique, core and coat types, core-to-coat ratio, and drug loading all had an effect on entrapment efficiency and release. Lipospheres were relatively stable after 3 months of storage at 2-8°C, as evidenced by a low leakage rate (less than 7%) and no significant changes in particle size. Liposphere systems showed to be a promising topical system for the administration of luliconazole since they could entrap the drug at extremely high levels and with high stability, as well as sustain the drug's antifungal activity.

Anti-fungal, Lipospheres, Luliconazole, entrapment efficiency, stability test.

"FORMULATION AND EVALUATION OF LULICONAZOLE LOADED NANOLIPOSPHERES FOR TOPICAL DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 2, page no.d26-d38, February-2025, Available :http://www.jetir.org/papers/JETIR2502304.pdf

"FORMULATION AND EVALUATION OF LULICONAZOLE LOADED NANOLIPOSPHERES FOR TOPICAL DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 2, page no. ppd26-d38, February-2025, Available at : http://www.jetir.org/papers/JETIR2502304.pdf