• Ms. Simran Chauhan
• Ms.Siddhi Parmer
• Mrs. Harshala Patil

The solubility has a direct impact on medication absorption, bioavailability, and therapeutic results, it is essential in assessing the efficacy of pharmaceutical substances. The low water solubility of a large number of recently produced active pharmaceutical ingredients (APIs) presents difficulties for medication formulation and administration. Numerous Solubilization methods have been investigated in an effort to increase systemic absorption and medication dissolving rates. Solubility enhancement strategies are thoroughly examined in this review, including advanced techniques like surfactant-based Solubilization, supercritical fluid processing, and self-emulsifying drug delivery systems, as well as physical modifications like particle size reduction, solid dispersion, and nanotechnology, as well as chemical modifications like salt formation, co-crystallization, and pH adjustment. In order to improve therapeutic performance and commercial feasibility, these methodologies' benefits, drawbacks, and real-world uses in pharmaceutical research are examined. By overcoming solubility challenges, these strategies contribute to the successful formulation of potent and effective therapeutic agents.

Solubility, Bioavailability, Drug Delivery, Solubilization Techniques, Formulation

"A COMPREHENSIVE REVIEW ON SOLUBILITY ENHANCEMENT STRATEGIES FOR POORLY WATER-SOLUBLE DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 2, page no.e390-e400, February-2025, Available :http://www.jetir.org/papers/JETIR2502442.pdf

"A COMPREHENSIVE REVIEW ON SOLUBILITY ENHANCEMENT STRATEGIES FOR POORLY WATER-SOLUBLE DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 2, page no. ppe390-e400, February-2025, Available at : http://www.jetir.org/papers/JETIR2502442.pdf