• Kodishwaran R
• Natarajan P
• Vigneswaran R
• Monisha V
• Sineha M

AIM: The present study investigates the anti-inflammatory activity of hydroalcoholic extract from Catharanthus roseus flowers in chicks. Recognized for its traditional medicinal applications, Catharanthus roseus contains bioactive compounds with potential therapeutic effects. The study begins with the collection and authentication of plant material from Virudhunagar District, Tamil Nadu, followed by extraction using a hydroalcoholic solution. Preliminary phytochemical analysis confirms the presence of flavonoids, alkaloids, glycosides, steroids, terpenoids, reducing sugars, quinones, tannins, and phenolic compounds. METHOD: In the pharmacological evaluation, acute toxicity studies guided dose selection. Chicks were divided into five groups, including a normal control, a carrageenan-induced inflammation control, a standard treatment with indomethacin, and two test groups receiving Catharanthus roseus flower extract (CRFE) at 100 mg/kg and 150 mg/kg. Inflammation was induced using a carrageenan-induced foot edema model, with subsequent measurement of foot volume to assess inflammation. RESULTS: It demonstrated a dose-dependent anti-inflammatory effect of CRFE, with the higher dose (150 mg/kg) showing significant activity compared to the lower dose (100 mg/kg) and the control group. Statistical analysis using ANOVA confirmed the significance of these findings (p < 0.05). These findings suggest that CRFE possesses substantial anti-inflammatory properties, warranting further investigation into its therapeutic potential and underlying mechanisms. CONCLUSION: It based on the results, it appears that the hydroalcoholic extract of Catharanthus Roseus flowers may have anti-inflammatory effects in chicks, with the higher dose showing s more prominent effect. Further studies, including additional parameters and mechanisms, would be valuable to better understand the potential therapeutic applications of CRFE in inflammation.

Catharanthus roseus, Anti-inflammatory, Chicks, Carrageenan-induced inflammation, Herbal medicine.

"EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CATHARANTHUS ROSEUS FLOWERS IN CHICKS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 2, page no.g54-g61, February-2025, Available :http://www.jetir.org/papers/JETIR2502608.pdf

"EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CATHARANTHUS ROSEUS FLOWERS IN CHICKS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 2, page no. ppg54-g61, February-2025, Available at : http://www.jetir.org/papers/JETIR2502608.pdf