• SRESTHA DAS
• TAMALIKA CHAKRABORTY
• SHREYA BANERJEE
• SAMADRITO CHATTERJEE
• AYANTIKA SAMANTA

This review paper delves into the potential of Chinese medicinal plants and their bioactive compounds to combat antibiotic-resistant pathogens through anti-biofilm activities. Biofilms, which are structured microbial assemblies within extracellular polymeric substances, play a pivotal role in the persistence of infections and heightened resistance to standard antibiotics. The study outlines the phases of biofilm development—from initial adhesion and micro-colony formation to maturation and eventual dispersal—emphasizing the significance of quorum sensing and extracellular matrix dynamics in these processes. It further investigates how bioactive compounds, including flavonoids, alkaloids, terpenoids, and polyphenols, inhibit biofilm formation by disrupting quorum sensing pathways, destabilizing extracellular matrices, altering microbial cell wall integrity, and affecting surface adhesion. Prominent bioactive substances such as baicalin, berberine, and epigallocatechin gallate exhibit strong anti-biofilm effects in both laboratory (in vitro) and live organism (in vivo) settings, enhancing the efficacy of traditional antibiotics. The paper also explores the synergistic benefits of combining plant-derived extracts with antibiotics, presenting promising approaches to address multidrug-resistant infections. While the results are encouraging, the paper acknowledges challenges like inconsistencies in plant composition, bioavailability limitations, and regulatory obstacles. Future research directions include standardizing of extraction methods, improving of drug delivery systems, and executing of rigorous clinical trials to substantiate the therapeutic potential of these natural compounds in treating biofilm-associated infections.

Anti-biofilm, Quorum sensing, Surface adhesion, Bioactive compound, Multidrug-resistant

"ROLE OF CHINESE MEDICINAL PLANTS AND ITS BIOACTIVE COMPOUNDS CONFERRING ANTI BIOFILM PROPERTY AGAINST ANTIBIOTIC RESISTANT PATHOGENS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 2, page no.g102-g128, February-2025, Available :http://www.jetir.org/papers/JETIR2502614.pdf

"ROLE OF CHINESE MEDICINAL PLANTS AND ITS BIOACTIVE COMPOUNDS CONFERRING ANTI BIOFILM PROPERTY AGAINST ANTIBIOTIC RESISTANT PATHOGENS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 2, page no. ppg102-g128, February-2025, Available at : http://www.jetir.org/papers/JETIR2502614.pdf