• Prabhanshu Singh
• Dr. Amit Kumar Keshari

An essential component of research into finding and maximizing substances for medicinal application is drug design & development. The goal of this technique is to find compounds that may selectively and effectively interact with biological targets by integrating principles from a variety of fields, such as chemistry, biology, pharmacology, and computer science. Technological developments, especially in computational biology and techniques, have completely changed the drug discovery process by making it possible to rationally design compounds with improved safety and efficacy profiles. An outline of the main phases of drug development is given in this abstract, including target validation and identification, lead optimization, and preclinical research. The significance of comprehending target structures and mechanisms is emphasized, along with the use of cutting-edge methods including virtual screening, molecular modeling, and structure-activity relationship (SAR) research. In addition, ways to deal with problems including medication resistance, pharmacokinetic variability, and toxicity evaluation are covered. Delivering safe and effective treatments that answer unmet medical needs is the ultimate goal of drug design, highlighting the multidisciplinary nature and constantly changing approaches in this dynamic discipline.

Novel drug design, AI-driven discovery, Computational modeling, Targeted therapy, Machine learning, Molecular docking, QSAR, Personalized medicine, Drug repurposing, CRISPR, Pharmacogenomics

"NOVEL APRROACHES IN DRUG DESIGN & DEVELOPMENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 3, page no.f273-f293, March-2025, Available :http://www.jetir.org/papers/JETIR2503564.pdf

"NOVEL APRROACHES IN DRUG DESIGN & DEVELOPMENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 3, page no. ppf273-f293, March-2025, Available at : http://www.jetir.org/papers/JETIR2503564.pdf